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Перевод: alkalinization

подщелачивание

Тезаурус:

1. External trimethylamine base (TMA) and acetic acid (Ac) (time of application indicated by open bars) increased or decreased BCECF fluorescence (at 530nm wavelength) excited at 490nm, owing to alkalinization and acidification of the cell, but did not alter fluorescence excited at 440nm (near the isosbestic wavelength: record obtained just after the 490nm record from the same cell).
2. These data show that the glutamate uptake carrier generates an extracellular alkalinization and an intracellular acidification by transporting a pH-changing anion, presumably OH - or HCO, out of the cell.
3. Here we show that the carrier generates an alkalinization outside and an acidification inside glial cells, and transports anions out of the cells, suggesting that there is a carrier cycle in which two Na + accompany each glutamate anion into the cell, while one K + and one OH - (or HCO) are transported out.
4. Prolonged activation of uptake, as may occur during epileptic seizures or in the retina where glutamate is released tonically, can lower the intracellular pH significantly, and a larger alkalinization is expected in the extracellular space, which is of smaller volume.