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Перевод: allelic

аллельный

Тезаурус:

1. In spite of increasing knowledge about the gene, at the present time the only way to distinguish between Duchenne muscular dystrophy and the more benign allelic Becker muscular dystrophy is by muscle biopsy and dystrophin analysis.
2. Suppose it happened to bias meiosis in such a way that it, the mutant gene itself, was more likely than its allelic partner to end up in the egg.
3. In contrast, allelic losses on chromosomes 17 and 18 confer a poor prognosis independent of conventional staging as do a combination of c-ki-ras gene mutations and p53 overexpression, as measured immunohistochemically.
4. For instance, while deletion of DCC on chromosome 18q is present in 75% of cancers, only 11% of adenomas show allelic loss.
5. The peptides from CSP which bound to HLA-B53, that is, cp6, cp6.1 and cp6.2 are allelic variants.
6. Allelic losses, insertions, and point mutations have been detected on many other chromosomes but it has still to be established whether such changes function simply as markers for colorectal cancer, or as potential prognostic indicators.
7. Adenoma cells converted to anchorage independent growth and tumorigenicity by MNNG (N-methy-N-nitro-N-nitrosoguanidine), display aneuploidy, allelic loss on chromosome 1p, and deletion of chromosome 18.
8. To estimate the relative frequencies of the four allelic variants cp26-cp29 in P. falciparum in The Gambia, DNA was analysed from samples collected from 156 children with acute malaria.
9. Cp6 bound more strongly to HLA-B51 than to HLA-B53 but the allelic variants of this peptide with single amino-acid substitutions at position 4, cp6.1 and cp6.2, bound more strongly to HLA-B53 and very poorly to HLA-B51 (data not shown).
10. The ALDH2 gene exists in at least two allelic forms, ALDH2*1 and ALDH2*2.
11. In assay 2, these peptides and cp29, which are four allelic variants (Table 2), were tested individually, again at an effector to target cell ratio of 50:1.
12. So, all possible peptides with proline at 2 and tyrosine at 8 or 10, as well as their allelic variants, were also tested.
13. A segment of the CSP gene containing the DNA encoding this epitope was amplified by PCR and the allelic variants detected by specific oligonucleotide probes.