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Перевод: atherosclerotic

атеросклеротический

Тезаурус:

1. Fissuring of an atherosclerotic plaque would also expose collagen fibres, and the adhering platelets could release agents such as thromboxane A 2 and ADP, which would rapidly lead to adhesion and aggregation of more platelets and growth of the thrombus.
2. The fact that this early lesion is intimal suggests a response to a factor or factors in the blood, and the "response to injury" hypothesis is central to current thinking on the atherosclerotic process.
3. Increased thromboxane A 2 production may also contribute to thrombogenesis in atherosclerotic vessels.
4. As the atherosclerotic process progresses, blood flows less easily through rigid and narrowed arteries and the turgid blood is more likely to form a thrombosis (or clot).
5. Thus the production of prostacyclin by cultured smooth muscle cells obtained from plaques of the experimental atherosclerotic rabbit consistently produced less prostacyclin when compared to control cells (Larrue et al, 1980).
6. The already high incidence of vascular disease in non-diabetic western populations appears to be still higher in diabetic subjects and, although there have been suggestions of a specific diabetic large-vessel disease (Lundbaek, 1973), there is little evidence to suggest that atherosclerotic lesions in diabetics are distinct from those in non-diabetics (Strandness et al, 1964).
7. All these factors make smokers more at risk of developing various forms of atherosclerotic disease.
8. Of course the advanced atherosclerotic plaque is a very complex structure, but the early lesion is very much a process which involves the intima of the artery and is characterised by proliferation of smooth muscle cells which have migrated from the media of the artery (Woolf, 1983).
9. Furthermore, prostacyclin production measured by bioassay and 6-oxo-prostaglandin Fsub1 concentrations was reduced in perfused heart preparations from atherosclerotic rabbits (Dembinska-Kiec et al, 1977).
10. Similarly, prostacyclin production in human atherosclerotic tissue appears to be reduced.
11. In addition, prostacyclin generation is probably reduced in the region of the atherosclerotic plaque, possibly due to the high content of lipid peroxides in advanced atherosclerotic lesions (Glavind et al, 1952).
12. Sinzinger et al (1979) demonstrated decreased prostacyclin generation from atherosclerotic tissue compared to normal arterial tissue and could find no difference between early and advanced lesions.