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Перевод: intraperitoneal

внутрибрюшинный

Тезаурус:

1. Several groups, each consisting of eight to 10 rats with gastric ulcers, were used in two series, A and B. In series A, group I rats were treated with vehicle (saline, 1 ml given by intragastric route three times daily) only (control); group II rats were given intragastric bFGF (3, 30, or 300 g/kg/day in three equal doses, each dose dissolved in 1 ml of saline), group III rats were given bFGF by intraperitoneal injection (3, 30, or 300 g/kg/day in three equal doses), group IV rats were treated with intragastric sucralfate (added to drinking water; 400 mg/kg/day); group V rats were treated with a combination of intragastric bFGF (30 g/kg/day in three equal doses) plus sucralfate; group VI rats were treated with intraperitoneal bFGF (30 in three equal doses); and for comparison group VII rats were treated with omeprazole (60 mg/kg/day into the peritoneum in two equal doses each dissolved in 1 ml of saline).
2. Rats of series B were divided into group I treated with vehicle (saline) alone; group II treated with daily intraperitoneal injection of indomethacin (2 mg/kg); group III treated with sucralfate (400 mg/kg/day); and group IV, treated with a combination of indomethacin (2 mg/kg) plus sucralfate (400 mg/kg).
3. To rule out the possible influence of intraperitoneal sequelae of the operation, only animals with no or slight adhesions in the area of the operation were included.
4. The rats were anaesthetised either by a subcutaneous injection of urethane (1.5 g/kg) or an intraperitoneal injection of sodium phenobarbital (0.23 g/kg).
5. To counteract the respiratory impairment associated with the administration of capsaicin, the rats received an intraperitoneal injection of atropine (0.2 mg/kg), terbutaline (0.2 mg/kg) and aminophylline (20 mg/kg) before the first and third capsaicin or vehicle injection.
6. In b, cells in S phase were labelled in vivo by an intraperitoneal injection of BrdU (0.1mgg -1 body weight; Boehringer-Mannheim), which is incorporated into replicating DNA.
7. With duplex Doppler scanning of the common femoral vein in humans we have shown a considerable reduction in peak blood flow velocity and shortening of the flow cycle during the respiratory phase on two occasions, with a return to normal venous blood flow characteristics on removal of the intraperitoneal gas.
8. Mice were given enough avertin by intraperitoneal injection to induce very light anaesthesia.
9. Rats were given an intraperitoneal injection of BrdUrd (60 mg-kg body weight) one hour before sacrifice.
10. Administration of bFGF (3-;300 g/kg/day) by an intragastric or an intraperitoneal route or sucralfate (400 mg/kg/day) orally to rats with acetic acid induced gastric ulcers, enhanced the healing rate of these ulcers during seven day treatment in a dose dependent manner.
11. The reduction in the ulcer area after treatment with intraperitoneal bFGF at a dose of 30 g/kg/day was comparable with that obtained with omeprazole at a dose of 60 mg/kg/ day - namely, almost complete inhibition of gastric acid secretion (Table II).
12. Intraperitoneal injections are given while holding the animal as in Figure lb on its back with the head slightly down.