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Перевод: scleroderma

склеродермия

Тезаурус:

1. Furthermore, raised plasma ET-1 concentrations and ET-1-induced deposition of collagen by fibroblasts have been reported in patients with scleroderma and systemic sclerosis.
2. Eighteen of the disease control subjects had irritable bowel syndrome, five had bacterial overgrowth of small intestine from pseudo-obstruction (three) or advanced scleroderma (two), and three had Crohn's disease of the terminal ileum.
3. Interestingly 20 of 23 severe oesophagitis patients smoked or drank heavily and of those who claimed no such history one had scleroderma and another may not have disclosed full details.
4. One major or two minor criteria were required for the diagnosis; the major criterion was scleroderma affecting the digits, forearms or face (15 patients); minor criteria were sclerodactyly alone (10 patients), distal pitting scars of finger tips (10 patients), loss of substance of the distal finger pads (nine patients) and bilateral pulmonary fibrosis (seven patients).
5. Our finding that only one in 10 asymptomatic patients with know connective tissue disease had a manometric abnormality is at variance with previous studies in patients with scleroderma and mixed connective tissue disease.
6. This is most often a primary disorder in children but in adults is more commonly secondary to diseases such as diabetes mellitus or scleroderma.
7. An autoimmune basis has been suggested as PHT can be associated with rheumatological conditions including systemic lupus, scleroderma, and its CREST variant, mixed connective tissue disease, primary Sjogren's disease, and rheumatoid arthritis.