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Перевод: acyclovir
ацикловир
Тезаурус:
- Wellcome said that the results are consistent with an earlier study, which showed improved survival of patients with advanced HIV infection taking a combination of zidovudine and acyclovir.
- The trial was halted after one year instead of the planned three after 20 per cent of patients taking only zidovudine died compared with only 10 per cent of those taking a "cocktail" of zidovudine and acyclovir.
- Acyclovir's anti-viral activity is based on just the kind of selective enzyme interactions outlined above.
- The structure of acyclovir shares crucial features in common with two of the precursors of DNA-thymidine and deoxycytidine (Figure I).
- Wellcome sells over 100 prescription products including Retrovir (AZT or zidovudine) and Zovirax (acyclovir), both of which are anti-viral drugs.
- Wellcome's share price rose sharply at the beginning of the year after the announcement that a combination of two of its drugs, Retrovir (zidovudine or AZT) and Zovirax (acyclovir), halved the number of deaths amongst Aids patients compared to zidovudine alone.
- Because of its similar structure acyclovir can also receive a phosphate group from the thymidine/ deoxycytidine kinase enzyme.
- One of the most publicised of the new anti-viral agents (and one of only three anti-viral, drugs currently listed for prescription in the UK Monthly Index of Medical Specialities) is acyclovir - the trade name for 9-(2-hydroxyethoxymethyl) guanine.
- The newer antiherpes agent, acyclovir, is of great interest, because it acts in virally-infected cells, but only to a negligible extent in healthy human cells.
- This is the first step in the conversion of acyclovir into its anti-viral form.
- The finding that the death rate of patients was reduced in the group taking zidovudine and acyclovir in combination was a "very incidental result", according to a spokeswoman from Wellcome.
- According the Wellcome the study was set up to look at the effect of acyclovir against cytomegalovirus, a type of herpes virus, and was stopped after no difference was found in frequency of CMV disease between patients taking acyclovir and those taking a placebo.
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