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Перевод: folic

фолиевый

Тезаурус:

1. Was folic acid necessary for abnormal proliferation?
2. PABA is essential for those microbes which are attacked by sulphonamides (see Chapter 8) and the discovery of folic acid threw fresh light on the way sulphonamides worked.
3. Folic acid itself is of great interest to anyone concerned with the formation of red and white blood cells, and with the abnormal and excessive formation of white cells in leukaemia.
4. This point was rapidly settled when folic acid was shown not to check but to accelerate the development of certain leukaemias.
5. The exact structure of folic acid was established in 1946.
6. This discovery suggested that an analogue of folic acid would block its use and prevent the multiplication of blood cells, just as an analogue of PABA prevented the multiplication of microbes which used PABA.
7. Most organisms, ranging from other microbes to man, can absorb folic acid and rely on it to provide their needs, and so they are not affected by sulphonamides.
8. Theoretically, the sulphonamide block could be by-passed if ready-made folic acid were available, but in practice microbes which make their own folic acid are unable to take it up from outside.
9. Gradually it became clear that all these factors were chemically identical, and the single name, folic acid, was coined.
10. Now the identity of the further blocks was known, and it was evident that sulphonamides prevented folic acid from being put together.
11. PABA, glutamic acid, and a source of pteridine, are the building blocks from which the microbe constructs its own folic acid.
12. I should have thought Professor Lejeune's research and clinical findings on prevention of deterioration in Down's children by administration of folic acid or thyroxine in appropriate cases to be particularly newsworthy.